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Eu-Train

The European Transplantation and Innovation consortium for risk stratification in kidney transplant patients

5
YEARS PROJECT 2018-2022
12
PARTNERS
6
EUROPEAN COUNTRIES
6.6
MILLIONS EUROS FUNDING

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End stage renal diseases affect more than 3,900,000 patients worldwide with approximately 6% growth rate in 2016.

Kidney transplantation is currently the best therapeutic option with around 1,500,000 patients living with a kidney transplant. However, long-term graft survival has not been improved in the past 15 years and rejection is a major cause of graft loss, representing at least 12 billion € extra costs per year.

There is a major unmet need: a lack of robust tools to stratify the risk of rejection, graft function decline and graft loss.

To tackle this issue, the EU-TRAIN project aims at developing a risk stratification system in kidney transplantation by integrating multidimensional data from patients’ follow-up.

OUR GOALS AMBITIOUS BUT REALISTIC - home4

Our goals ambitious but realistic

Our main goal is to answer the medical need for a precision risk stratification system in kidney transplant patients:

Goal 1:
Identify low- and high-risk kidney transplant patients using invasive and non-invasive biomarkers
Goal 2:
Implement blood non-invasive biomarkers to reduce invasive allograft biopsies
Goal 3:
Combine biomarker-guided strategy with traditional risk factors to stratify the risk of rejection, response to treatment, long-term allograft loss and allograft function decline
Goal 4:
Improve allograft outcomes

HOW WILL WE ACHIEVE OUR GOALS? - home5

How will we achieve
our goals?

  • 1 Develop an integrated risk-stratification and prognosis system (EU-TRACER)
    in kidney transplantation to improve graft survival
  • 2 Convert EU-TRACER into clinical actionable information for the clinician:
    - individual risk prediction for 3, 5, 7, 10-year allograft loss
    - in high-risk rejecting patients: probability of response to standard of care
    treatment and impact on outcomes
  • 3 Evaluate the EU-TRACER system in a “real-life” prospective randomized
    control trial

THE PROJECT OBJECTIVES - home6

The project objectives

1.Build Europe’s largest deep-phenotyped kidney transplant cohort/group by combining existing European databases and infrastructures
2.Correlate traditional risk factors for allograft rejection and loss & new risk factors defined by cutting-edge technologies based on disease mechanistic
3.Build a precision risk stratification system (EU-TRACER) that calculates individual risk of allograft rejection and transplant failure based on the smart data integration of the overall spectrum of relevant traditional and new prognostic factors, allowing evidence-based decision making for maintenance of immunosuppressive regimens
4.Engage European and international authorities to translate our consortium’s findings into European and international policies and thus prevent kidney allograft failure and improve patient survival

PARTNERS - home7

Partners

Thiên-Ly PHAM

European Project Manager

thien-ly.pham@inserm-transfert.fr

Phone : +33 1 55 03 01 35

 

Inserm Transfert

7 rue Watt

75013 Paris

France

www.inserm-transfert.fr

 

EU-TRAIN is a research program. The content of this website is not intended to give medical diagnosis, treatment or medical advice.

All rights reserved.

This information may be freely used and copied for educational and other non-commercial purposes, provided that any reproduction of data be accompanied by an acknowledgement of EU-TRAIN as the source (© EU-TRAIN).

This does not apply to the pages and images with explicitly reserved reproduction right : © followed by the right owner and the year of first circulation. Reproduction of the latter requires prior authorization from EU-TRAIN for the pages.

 

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According to the Law n°78-17"Informatique et Libertés/software and freedoms" and its amendments, users have the right to access, modify, correct and delete any personal data collected when visiting the site. The users can exercise such rights with:

Inserm Transfert
7 rue de Watt
75013 Paris, France

©2018 EU-TRAIN

Programming: ML-Com, France
Hosting : OVH 140 quai du Sartel 59100 Roubaix - 0899 701 761

Privacy Policy

Inserm Transfert will not to reveal information obtained from users. Such information is confidential and will only be used with users consent. 
According to the Law n°78-17 "Informatique et Libertés/software and freedoms" and its amendments, users have the right to access, modify, correct and delete any personal data collected when visiting the site.

The users can exercise such rights with:

Inserm Transfert
7 rue de Watt
75013 Paris, France
©2018 EU-TRAIN